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Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.
Strategic Horizons | Learn about Spruce's expansion into MDD and PCOS treatments, diversifying beyond CAH and potentially reshaping the company's market position and valuation |
Financial Health | Discover Spruce's $70M cash position, runway through 2025, and efficient cash management, balanced against rapid cash burn and market cap challenges |
Market Dynamics | Delve into the competitive landscape of CAH treatment, with Spruce Biosciences vying against Neurocrine's crinecerfont in a market of 20,000-30,000 U.S. patients |
Tildacerfont Trials | Explore the pivotal CAHmelia-204 and CAHptain-205 trials, testing tildacerfont's efficacy in reducing glucocorticoid doses while maintaining androgen control in CAH patients |
Metrics to compare | SPRB | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipSPRBPeersSector | |
|---|---|---|---|---|
P/E Ratio | −2.4x | −3.4x | −0.5x | |
PEG Ratio | −0.05 | −0.09 | 0.00 | |
Price / Book | 2.2x | 15.1x | 2.6x | |
Price / LTM Sales | - | 20.9x | 3.2x | |
Upside (Analyst Target) | 172.9% | 56.8% | 45.7% | |
Fair Value Upside | Unlock | 2.7% | 4.8% | Unlock |